Maxigen

Introduction:

Description

The combination of amoxicillin and gentamicin acts synergistically against a wide range of infections caused by both Gram-positive (e.g. Staphylococcus, Streptococcus and Corynebacterium spp.) and Gram-negative (e.g. E.coli, Pasteurella, Salmonella and Pseudomonas spp.) bacteria in cattle and swine. Amoxicillin inhibits mainly in Gram-positive bacteria the cross-linkage between the linear peptidoglycan polymer chains that make up a major component
of the cell wall. Gentamicin binds to the 30S subunit of the ribosome of mainly Gram-negative bacteria, thereby interrupting protein synthesis.

Indications

Cattle:
gastrointestinal, respiratory and intramammary infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, diarrhoea, bacterial enteritis, mastitis, metritis and cutaneous abscesses.

Swine:
respiratory and gastrointestinal infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, colibacillosis, diarrhoea, bacterial enteritis and mastitis-metritis-agalactia syndrome (MMA).

Contra indications

Hypersensitivity towards amoxicillin and/or gentamicin.
Administration to animals with a seriously impaired hepatic and/or renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Concurrent administration of nephrotoxic and/or ototoxic preparations, intravenous calcium supplementation, iron supplementation and non-steroidal antiinflammatory preparations.

Side effects

Hypersensitivity reactions.

Dosage

For intramuscular administration. The general dosage is 1 ml per 10 kg body weight per day for 3 days.

Cattle:
30 - 40 ml per animal per day for 3 days.

Calves:
10 - 15 ml per animal per day for 3 days.

Swine:
5 - 10 ml per animal per day for 3 days.

Piglets:
1 - 5 ml per animal per day for 3 days.

Shake well before use. Do not administer more than 20 ml in cattle or more than 10 ml in swine and more than 5 ml in calves per injection site to favour absorption and dispersion.

Withdrawal times

- For meat : 30 days.
- For milk : 2 days.